Rat strains suitable for high fat diet studies

By | April 15, 2021

rat strains suitable for high fat diet studies

In the past decades, obesity and associated metabolic complications have reached epidemic proportions. For the study of these pathologies, a number of animal models have been developed. However, a direct comparison between Wistar and Sprague-Dawley SD Rat as models of high-fat HF diet-induced obesity has not been adequately evaluated so far. Wistar and SD rats were assigned for 2 experimental groups for 17 weeks: standard St and high-fat HF diet groups. To assess some of the features of the metabolic syndrome, oral glucose tolerance tests, systolic blood pressure measurements and blood biochemical analysis were performed throughout the study. The gut microbiota composition of the animals of each group was evaluated at the end of the study by real-time PCR. HF diet increased weight gain, body fat mass, mesenteric adipocyte’s size, adiponectin and leptin plasma levels and decreased oral glucose tolerance in both Wistar and SD rats. However, the majority of these effects were more pronounced or earlier detected in Wistar rats.

Stephen C. Woods, Randy J. Seeley, Paul A. The prevalence of obesity is increasing. Although the etiology of obesity is complex, dietary factors, particularly the consumption of a high-fat HF diet, is considered a risk factor for its development. Nonetheless, a causal role of dietary fat has never been definitively documented, in part because of inadequate animal models. We developed a rat model of diet-induced obesity that will be a powerful tool for assessment of this issue.

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J Obes. Figure 8. Because Sprague-Dawley rats did not develop diet-induced obesity in our experiments, we were able to observe effects of the diet on pain sensitivity in the absence of elevated body weight or adiposity. Figure 1. A quick model for the induction of metabolic syndrome markers in rats. Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. However, GK rats only act as genetic model representing certain aspects of MetS thus not a suitable animal model to represent MetS. The width was measured at the point of widest medial-lateral distance, which was always near the heel. Global obesity: trends, risk factors and policy implications. Ble-Castillo JL, et al.

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